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This Account highlights the development and implementation of ultra-pH-sensitive (UPS) nanoparticles in cancer immunotherapy with an emphasis on nanoscale cooperativity.

UPSM undergo micelle−unimer phase transition at their apparent pKa, with dramatically increased buffer capacity in a narrow pH range (<0.3 pH).

In cancer therapy, the inner region of a tumor is commonly hypoxic (b20 mmHgO2 pressure) [14] due to in- sufficient blood supply.

A profile on Chantal Vidal, who researches treatment resistance in advanced breast cancer as a PROVIDES postdoctoral scholar at UT Southwestern.

Sumer, MD Objectives/Hypothesis: Folate receptor (FR) expression, although known to be elevated in many types of cancer and inflammatory cells, has not been well characterized in head and neck squamous cell carcinoma (HNSCC).

Malladi Lab Manuscript Published in Nature Communications

Information regarding User Group A, Discovery of PET Applications & Imaging Metabolic Alterations in Pediatric Oncology, for UT Southwestern's Cyclotron and Radiochemistry Program Pediatric Core.

Malladi Lab Manuscript Published in Nature Communications

In this paradigm, image-guided RF ablation will first provide instantaneous destruction of the majority of the liver tumor by heat.

Proliferation of multiple cancer cell types was inhibited. Nitin and co-workers designed an Alexa-647 labeled pHLIP for the imaging of variations in extracellular pH in head and neck squamous cell carcinoma. The fluorescence intensity is 4−8-fold higher in cancer tissues over healthy tissues.